
Though sadness is a common and normal human emotion, it is important to know if your sadness is causing an underlying brain illness called major depression.
MDD is the most common and serious mental health condition characterized by persistent feelings of sadness, hopelessness, and a loss of interest in activities. It can manifest with behavioral, affective, cognitive, and somatic symptoms.
If you are experiencing symptoms of depression, it’s important to recognize and address them.
- Persistent feelings of sadness, emptiness, or hopelessness
- Increased anxiety – Irritability or agitation
- Anhedonia, which is the inability to experience joy or pleasure
- A loss of interest in activities that you once enjoyed
- Changes in appetite or sleep patterns
- Fatigue or a decrease in energy levels
- Difficulty concentrating or making decisions
- Feelings of worthlessness or guilt
- Challenges with concentration or memory
- Recurring thoughts about death or suicidal ideation
Identifying these feelings is the first step toward seeking support and finding effective treatment. Remember that with CIHS, you are not alone, as many resources are available to help you navigate these challenges.
- Genetic predisposition: family history, especially first-degree relatives with MDD
- female gender
- postpartum period
- medical condition
- significant environmental stressors like death and losses
- prior episode of MDD
- Genetics: A family history of depression can increase the likelihood of experiencing it.
- Biological Factors: Imbalances in neurotransmitters (chemicals in the brain) such as serotonin, norepinephrine, and dopamine can contribute to depression.
- Medical Conditions: Certain medical conditions like chronic illnesses, hormonal changes, or neurological disorders can contribute to depressive symptoms.
- Psychological Factors: Individuals with low self-esteem, a pessimistic outlook, or a history of trauma are at a higher risk.
- Substance Abuse: Alcohol or drug abuse can lead to or worsen depression.
- Life Event: Stressful life events such as the loss of a loved one, job loss, or any major life change can trigger depression
- Environmental Factors: Conditions such as living in an abusive or highly stressful environment can promote depression.
MDD can significantly impact an individual’s quality of life. At CIHS, our top goal is your safety. Treatment and management of MDD are available.

The symptoms may include:
Persistent sadness, helplessness, and a lack of interest or pleasure in daily activities affect overall well-being and managing the underlying medical condition effectively. Treatment often requires a comprehensive approach that addresses both the medical condition and the accompanying depressive symptoms.
Other depressive disorders



To manage depressive disorder, the most effective intervention is a combination of medication and psychotherapy.
- Different medications are used depending on the specific type and severity of depression, as each class of drugs works uniquely to relieve or prevent symptoms. The most common class is selective serotonin reuptake inhibitors (SSRIs). The therapeutic effects of these medications may take 4 to 6 weeks to manifest.
- Psychotherapy plays a crucial role in treatment. The primary approach is Cognitive-Behavioral Therapy (CBT), which focuses on recognizing and challenging negative thinking patterns and provides strategies for positive reactions.
- Other modalities might include exposure therapy or dialectical behavior therapy.
In Case of Emergency
- For suicidal ideation or any danger to self or others, call 911
OR
- go to the nearest hospital to learn how to seek help.
Resources:
- National Alliance on Mental Illness.
Call NAMI Helpline at 1800 950 NAMI (6264) In Crisis 988 (24/7) or info@nami.org
- National Institute of Mental Health (NIMH)
https://www.cdc.gov/reproductive-health/depression/resources.html